Separating Myth from Reality
On October 07, 2007 in Back to basic
Absinthe has always had an ambivalent history, on one hand it was praised as ‘The Green Muse’ by its devotees, and on the other it was condemned by it detractors as a cause of madness and moral degeneracy. But is there any scientific or medical basis for either position? Evidence for mind-altering effects is largely anecdotal and the frequently quoted first-hand descriptions of its mind-altering effects have come from artists and poets who may be expected to describe events in a fanciful manner.
Imbibers of alcohol have always described their favourite tipple in extravagant terms, whether it be Burns on whisky or Yeats on wine. The case for its harmful effect is largely based on research on laboratory animals conducted at the behest of the prohibitionist lobby and assumptions drawn from examinations of mental patients in the late 19th century.The origins of absinthe can be traced back to the end of the 18th century, when Pierre Ordinaire, a French doctor, used wormwood (Artemisia absinthium) together with anise, fennel, hyssop and various other herbs distilled in an alcoholic base as a herbal remedy for his patients.
Ordinaire’s recipe eventually found its way into the hands of Henri-Louis Pernod who established the Pernod fils dynasty when he opened his first distillery in 1805, and very soon ‘Extrait d’absinthe’ stopped being a local curiosity and started on its route to becoming a national phenomenon in France, and by the end of the 19th century it had been embraced by the Bourgeoisie and demi-monde alike with over 2 million litres being consumed annually in France.
So what is the published scientific evidence for the harm or benefits of absinthe? Wormwood has had a long history in folk medicine dating back as far as ancient Greece when it was variously prescribed for rheumatism, jaundice, menstrual pains and as an aid in child birth, but it only attracted scientific attention in the mid-19th century. At this time there was a powerful prohibitionist lobby gaining public attention throughout France and it should be noted that research was rarely totally independent and was conducted to support a particular position, for or against the banning of alcohol. The first published evidence for absinthe’s harmful effects in animals dates from the 1860s (Magnan V. Epilepsie alcoolique; action spéciale de l’absinthe: épilepsie absinthique. Comptus Rendu des Seances et Memoires de la Société de Biologie (Paris) 1869; 5(4th series): 156-61); (Amory R. Experiments and observations on absinthe and absinthism. Boston Medicaland Surgical Journal 1868; 7: 8:68-71, 83-5).
This purportedly shows that wormwood oil and alcohol produce a synergistic effect which leads to epileptiform convulsions. Magnan extended his studies to acute alcoholics and concluded that absinthe produced symptoms in humans that were distinct from alcoholic delirium tremens and manifest themselves as epileptic convulsions. However, it is now accepted that Magnan’s interpretations were oversimplified and alarmist. He not only concluded that absinthe caused medical and psychological troubles not associated with the high consumption of alcohol, he argued that absinthe’s deleterious effects were hereditary. Magnan was preoccupied with the degeneration of the French race, which he blamed on alcohol and in particular, absinthe. There should be no surprise at the correlation of absinthe drinking amongst the destitute and alcoholics, it was the cheapest way of buying strong alcohol. On the other hand, millions of French people enjoyed the occasional glass of absinthe after work without any ill effects.
Wormwood has also been shown to be a hepatoprotective. Gilani and Janbaz found that an extract of Artemisia absinthium protected against acetaminophen and carbon tetrachloride-induced hepatotoxicity in mice. The presence of antioxidants and calcium-channel blockers in wormwood also probably contributes to its hepatoprotective effects. (Gilani AH; Janbaz KH., Preventative and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity, Gen. Pharmacol, 1995, 26(2):309-315; Gilani AH. Search for new calcium channel blocking drugs from indigenous plants, International Congress on Natural Products Research, 1994, August 1-5, Halifax 0:29). Recent studies have demonstrated that extracts of wormwood (and other plants used in absinthe) have CNS cholinergic receptor binding activity and therefore contrary to accepted wisdom, absinthe may actually improve cognitive function (Wake et al, J Ethnopharmacol, 2000 Feb;69(2):105-14.
In conclusion, there is no evidence that absinthe ever contained the high concentrations of thujone that would have led to detrimental effects or that it has hallucinogenic or mind altering properties. The health problems experienced by chronic users were likely to have been caused by adulterants in inferior brands and by the high levels of alcohol present. Claims for beneficial effects must also be treated with some scepticism as again, the detrimental effects of the alcohol would presumably outweigh any benefits. It seems likely that the phenomenal success of absinthe during the 19th century was due to one factor, the French love of aniseed drinks. The modern equivalent of absinthe, pastis, is by far the most popular distilled spirit in France with 125 million litres being consumed annually. Perhaps the reason that so much absinthe was consumed, and absintheurs waxed so lyrically about it was simply because it tasted good.
source: feeverte.net